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CPSA USA 2014
Defining the Challenges of the Modern Analytical Laboratory:
The Risks and Reality of Personalized Healthcare
Updated October 7, 2014
Monday September 29
7:30 am - 8:30 am
Princeton Foyer
8:30 AM - 4:00 PM
Princeton I
9:00 AM - 3:00 PM
Makefield Highlands Golf Club, Yardley, PA
12:00 pm - 4:00 pm
Villanova Amphitheater
2:00 pm - 4:00 pm
University I
From Nature Products to Biologics – Applications of Advanced Analytical Technologies
Discussion Leaders: Ronald Kong, PTC; Min Liu, Merck; Jasmine Lu, Shimadzu
Interactions of Botanical Dietary Supplements with Drug Metabolizing Enzymes: Application of UHPLC-MS/MS
Richard van Breemen, University of Illinois at Chicago
Integration of Multiple Datasets: Big and Fast Data
Darryl Davis, Janssen
A Top-down MS/MS Approach to Characterize Product-related Impurities for Antibody Therapeutics
Yan-Hui Liu, Merck
Incorporating Novel Technologies in the DMPK Laboratory; Problems and Solutions using High-Resolution Mass Spectrometry for Biopharmaceutical Bioanalysis
Christopher Evans, GlaxoSmithKline
4:30 pm - 5:30 pm
University I/II
6:00 pm - 9:00 pm
University I/II
Sponsor's Reception & Dinner
Opening Remarks – Disease is the Enemy!
Paul Corcoran, McKinley Scientific; Gary Valaskovic, New Objective and Mike Lee, Milestone Development Services
CPSA Charitable Foundation
Paul Corcoran, McKinley Scientific; Emily Ehrenfeld, Mozaic Solutions; Joe Fox, AB SCIEX; Shane Needham, Alturas Analytics; Robyn Rourick, Genentech; Tony Yeung, Fox Chase Cancer Center
Distinguished Lecture Series
AB SCIEX
Translational Mass Spectrometry Enabling Personalized Medicines
Steven Wong
Wake Forest University
Tuesday September 30
7:30 am - 8:30 am
University Foyer
Registration & Continental Breakfast
7:30 am - 8:30 am
University I/II
Graduate Student/Mentor Breakfast
8:30 am - 9:00 am
University I/II
Welcome & Opening Remarks
Welcome
Mike S. Lee
Milestone Development Services
Format, Objectives, Opening Remarks
Paul Corcoran
McKinley Scientific
Gary Valaskovic
New Objective
9:00 am - 9:45 am
University I/II
Plenary Lecture
Adventures in Drug Discovery: Development of JANUVIA for Type 2 Diabetes
Ann Weber
Vice President, Merck
Villanova Amphitheater
TRACK I: Symposium Session
Current and Future Needs of Mass Spectrometry in Clinical Sciences
Discussion Leaders: Timothy Garrett, University of Florida and Kenneth Lewis, OpAns
Breaking Down Barriers to Adoption of Mass Spectrometry in the Routine Clinical Laboratory
Lori Bachmann, VCU
From Dried Blood Spots to Dried Urine Spots - Challenges and Advantages
David Millington, Duke University
Transforming the Application of MS in Clinical Sciences through Digital LC: What Would You Do with Infinite Speed?
Gary Valaskovic, New Objective
Princeton I/II
TRACK II: Colloquium Session
Crystal City V Guidance - How is the Guidance Being Used?
Discussion Leaders: Shane Needham, Alturas Analytics and Naidong Weng, Janssen Pharmaceuticals
CC V Interesting Outcomes
Mark Arnold, Bristol-Myers Squibb
Defining the Future of Clinical Protein Biomarker Discovery, Development and Deployment: Role of Pharma in Developing Companion Diagnostics
Binodh DeSilva, Bristol-Myers Squibb
Speakers/Panelists
Chad Briscoe, PRA Health Sciences
Binodh DeSilva, Bristol-Myers Squibb
Timothy Highman, Pfizer
Scott Reuschel, Tandem Labs, a LabCorp Company
Mark Stiles, Quality & Compliance Consulting
Eric Woolf, Merck
12:00 pm - 1:00 pm
University I/II
Sponsored Lunch & Roundtables
Biomedical Applications of UHPLC-MS/MS Using Shimadzu LCMS-8050 and LCMS-8040 Ultrafast Triple Quadrupole Mass Spectrometers
Richard van Breemen, University of Illinois at Chicago
Multiplexed Plasma Sampling From A Single Finger Stick
Fred Regnier, Purdue University and Novilytic Laboratories
1:00 pm - 3:00 pm
University Foyer
Poster Session & Roundtables
Discussion Leaders: Mark Cancilla, Merck; Helene Cardasis, Thermo Fisher Scientific; Matthew Szapacs, GlaxoSmithKline; Tracie Williams, CDC
University I
TRACK III: Symposium Session
Biomarkers and Diagnostics for Rare Diseases
Discussion Leaders: Michelle Clasquin, Agios and Roy Vaz, Sanofi
Metabolomics for Rare Diseases
Alla Kloss, Genzyme
Understanding N-Terminal Variation in Therapeutic Proteins by High Resolution Mass Spectrometry
Charles Cheng, Alexion Pharmaceuticals, Inc.
Diagnosis and Discovery of Treatable Inborn Errors of Metabolism via an Integrated -Omics Approach
Clara Van Karnebeek, BC Children's Hospital
University II
TRACK IV - Colloquium Session
Novel Solutions to Novel Milla & Macro-Molecule Analysis by LC/MS
Discussion Leaders: Mark Arnold, Bristol-Myers Squibb and Chad Briscoe, PRA Health Sciences
Trends in Peptide and Protein Quantification by LC-MS
Nico van de Merbel, PRA Health Sciences
Bioanalysis of Oligonucleotides using LC-MS: Challenges and Solutions
Laixin Wang, Tandem Labs, a LabCorp Company
It's "milla" Time
Timothy Olah, Bristol-Myers Squibb
4:45 pm - 5:15 pm
2nd Floor Lobby
Let Them Eat Cake!
5:00 pm - 6:00 pm
Social Hour & Sponsored Workshops
Princeton I
WORKSHOP
Innovative Bioanalytical Approaches for Biomarker Quantitation
Naidong Weng, Janssen Research and Development
High Throughput Functional Lipidomics: Putting Biology to Work for Theranostic and Biomarker Discovery
Michael Kiebish, BERG
Princeton II
WORKSHOP
Follow the Money - The Realities and Risks of Business and Science
Tim Garrett, University of Florida
Shane Needham, Alturas Analytics
Villanova Amphitheater
WORKSHOP
Cloud Based Solutions for Life Sciences & Healthcare
Andrey Bondarenko, InfoClinika
Nathan Yates, University of Pittsburgh
Lehigh
6:30 pm - 9:00 pm
Sponsor Hospitality & Evening Workshops
University I
Food Quality & Safety Summit
Discussion Leaders: Istvan Pelczer, Princeton University and David Perlman, Princeton University
An Overview of Analytical Technologies to Detect Adulteration of Botanical Ingredients in Dietary Supplements
Stefan Gafner and Mark Blumenthal, American Botanical Council
The New Normal - Changes in How Dietary Supplements Are Being Analyzed for Identity, Pesticides, Clandestine Adulteration and Other Compounds of Regulatory Concern under 21 CFR Part 111
Steven Royce, Agilent Technologies
Accurate Mass Q-TOF Utilizing a Personal Compound Database and Library for the Detection of Clandestine Phosphodiesterase-5 Inhibitor Adulteration in Men's Virility Formulations and Dietary Ingredients
Jerry Zweigenbaum, Agilent Technologies
University II
Microsampling Summit
Discussion Leaders: Qin Ji, Bristol-Myers Squibb and Olga Kavetskaia, AbbVie
Assuring the Quality of the Filter Paper Matrix
Victor DeJesus, CDC
Challenges of Quantitative Dried Spot Sampling in Clinical Diagnostics
Ken Lewis, OpAns
Update on Industry Status on Microsampling Research
Tim Olah, Bristol-Myers Squibb
Discussion Panel:
Donald Chace, Pediatrix Analytical
Victor De Jesus, CDC
Christopher Evans, GlaxoSmithKline
Kenneth Lewis, OpAns
Wenkui Li, Novartis
Timothy Olah, Bristol-Myers Squibb
Shane Needham, Alturas Analytics
Matthew Rieser, AbbVie
Yang Xu, Merck
Enaksha Wickremsinhe, Eli Lilly & Company
Wednesday October 1
7:30 am - 8:30 am
University Foyer
Registration & Continental Breakfast
8:30 am - 10:00 am
University I/II
Villanova Amphitheater
TRACK V: Symposium Session
Metabolomics - The Art and Lab Science of Expressionist Genetics
Discussion Leader: Don Chace, Pediatrix Analytical and Victor DeJesus, CDC
Second Tier Metabolic Assays: Improving Specificity by Adjusting the Hue of the Newborn Screen Picture
Victor DeJesus, CDC
Imaging MS: Painting Pictures of Disease with Ions
Timothy Garrett, University of Florida
Quantitation in Metabolomics - Minimalism vs Classical Approaches, How Much is Enough?
Petia Shipkova, Bristol-Myers Squibb
Princeton I/II
TRACK VI: Innovator Award Session
Innovative Technologies, Products and Services
Discussion Leader: Kevin Bateman, Merck
12:00 pm - 1:00 pm
Sponsored Lunch & Roundtable
University I & II
Exploration of Cloud-based Tools
Very High Resolution Spectral Library Trees Acquired Under Diverse Conditions
Accessible from the Cloud
Tim Stratton, Thermo Fisher Scientific
Re-Thinking and Re-Creating the Modern Scientific Data Analysis Paradigm:
Mass Spectrometry Moves Big Data out of the Lab and on to the Cloud
Nathan Yates, University of Pittsburgh
1:15 pm - 2:15 pm
Social Hour & Sponsored Workshops
Princeton I
WORKSHOP
LC-MS/MS Quantitative Analysis of Peptide Biomarkers in Human Body Fluids
Ron Huang, Biogen Idec
Tame the Flow: Macro and Micro Molecule Bioanalysis
Suma Ramagiri, AB SCIEX
Princeton II
WORKSHOP
Fast and Robust Quantitation: Nanospray MS for Biomarkers and Beyond
Welcome and Thank you
Gary Valaskovic, New Objective
Sliding into Multi-dimensiuonal, Multi-channel LC/LC-MS/MS Using the PicoSlide
Nathan Yates, University of Pittsburgh
Lipids and PicoChip LC-MS: Not Just for Proteomics Anymore
Susan T. Weintraub, University of Texas Health Science Center at San Antonio
Microspray and MicroFlow Liquid Chromatography: PicoFuze Technology for Modern LC-MS Bioanalysis
Shane Needham, Alturas Analytics
Villanova Amphitheater
WORKSHOP
Targeted Peptide Quantitation and Implications for Clinical Utility
What Can We Learn by Quantifying Peptides that Map within Various Regions of
the Hypercholesterolemia Causative Protein PCSK9 in Patient Cohorts?
Benoit Coulombe, Institut de Recherches Cliniques de Montréal (IRCM)
Development and Application of Automated, Highly Multiplexed immunoMRM
Eric Kuhn, The Broad Institute of MIT and Harvard
University II
Track VII - Symposium Session
Defining the Future of Clinical Protein Biomarker Discovery, Development and Deployment
Discussion Leader: Brad Ackermann, Eli Lilly and Company
Speakers/Panelists
Binodh DeSilva, Bristol-Myers Squibb
Andy Hoofnagle, University of Washington
Randall Nelson, Arizona State University
Hendrik Neubert, Pfizer
Nader Rafai, Childrens Hospital Boston
Russell Weiner, Merck
Villanova Ampitheatre
Steven A. Hofstadler Graduate Student Session
Inspiring Career Paths in the Sciences for Young Scientists
Mentors:
Sue Abbatiello, Thermo Fisher Scientific
Brad Ackermann, Eli Lilly and Company
Hong Cai, GlaxoSmithKline
Lucinda Cohen, Merck
Jonathan Josephs, Bristol-Myers Squibb
Kenneth Lewis, OpAns
Eric Milgram, PepsiCo
Shane Needham, Alturas Analytics
Timothy Olah, Bristol-Myers Squibb
Joanna Pols, Merck
Robyn Rourick, Genentech
Petia Shipkova, Bristol-Myers Squibb
Anthony Yeung, Fox Chase Cancer Center
Quantitative Measurements of Proteoform-Resolved Markers of Health and Disease
Timothy Toby, Northwestern University
Metabolomics Analysis of Skeletal Muscles and Fiber Types Using Mass Spectrometry
Yu-Hsuan Tsai, University of Florida
Fundamental Aspects of Quantitative Measurements in Complex Biological Systems: Considerations from a Systems Biology Approach
Phillip Loziuk, North Carolina State University
3:45 pm - 5:30 pm
Princeton I/II
Vendor Session - "Five Minutes of Fame"
Discussion Leaders: Mark Hayward, Active Ingredient Technologies; Matt Szapacs, GlaxoSmithKline; Nicole Donnelly, PharmaCadence
3:45 pm - 6:30 pm
University I & Lobby, 2nd Floor Lobby
Exhibition & Social Hour
Held in conjunction with the North Jersey ACS Mass Spectrometry Discussion Group and the Delaware Valley Drug Metabolism Discussion Group
6:30 pm - 7:30 pm
University II
CPSA Dinner Lectures & Award Presentations
CPSA Shanghai
Eric Yang, GlaxoSmithKline; Naidong Weng, Janssen Pharmaceuticals
CPSA Brasil
Paul Corcoran, McKinley Scientific; Gary Impey, AB SCIEX; Shane Needham, Alturas Analytics
Innovator Award Presentation
Kevin Bateman, Merck
Steven A. Hofstadler Graduate Student Award/Recognition
Presented by the Mentors
Program Chair Recognition
Mike Lee, Milestone Development Services
7:30 pm - 9:00 pm
University II
Keynote Lecture and
Presentation of the Distinguished Analytical Scientist Award
Keynote Lecture
Helping the Clinical Lab Help Patients
Andy Hoofnagle
University of Washington
Distinguished Analytical Scientist Award Presentation
Presented by Lucinda Cohen, Merck
Bioanalysis, Smart PK/PD and the Future of Drug Development
Kevin Bateman
Merck
Thursday October 2
7:30 am - 8:30 am
2nd Floor Lobby
Registration & Continental Breakfast
8:30 am - 10:00 am
Princeton I/II
Colloquia & Roundtables
Bioanalysis in Personalized Medicine: Where do Biomarkers Fit In?
Discussion Leaders: Noel Premkumar, Alturas Analytics and Jim Shen, Bristol-Myers Squibb
A Role for Mass Spectrometry in Personalized Medicine
Michael Lassman, Merck
Biomarkers and Personalized Medicine: Platforms, Compliance, Validations and Applications... and a Dozen More Choices
Patrick Bennett, PPD
A Discussion Surrounding Fit-For-Purpose Biomarker Validation
Jim Shen, Bristol-Myers Squibb
Villanova Amphitheater
Symposium Session
Measurement and Application of Metabolite Biomarkers
Discussion Leader: Petia Shipkova, Bristol-Myers Squibb
Metabolomic Applications for Discovery of New Targets in Sickle Cell Anemia
Annie Evans, Metabolon
Metabolic Consequences of Pyruvate Kinase Deficiency
Michelle Clasquin, Agios
The Use of Stable Isotopes in Translational Biomarker Development
David McLaren, Merck
12:00 pm - 1:00 pm
Princeton Foyer
Sponsored Lunch & Roundtables
Metabolic Phenotyping and Translational Medicine
Robert Plumb, Department of Surgery and Cancer, Imperial College, London
1:30 pm - 3:00 pm
Villanova Amphitheater
Symposia & Roundtables
New Alternative Instrumentation
Discussion Leaders: Kevin Bateman, Merck and Rick King, PharmaCadence
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